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KMID : 1188320170110020226
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Gut and Liver
2017 Volume.11 No. 2 p.226 ~ p.231
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Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease
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Lim Joo-Hyun
Kim Sang-Gyun
Song Ji-Hyun
Hwang Jae-Jin
Lee Dong-Ho
Han Jae-Pil
Hong Su-Jin
Kim Ji-Hyun
Jeon Seong-Woo
Kim Gwang-Ha
Shim Ki-Nam
Shin Woon-Geon
Kim Tae-Ho
Kim Sun-Moon
Chung Il-Kwon
Kim Hyun-Soo
Kim Heung-Up
Lee Joong-Yub
Kim Jae-Gyu
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Abstract
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Background/Aims: The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease.
Methods: Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regimens and durations, and types of peptic ulcers were analyzed.
Results: The overall eradiation rate was 71.6%. The adherence rate was 80.0%. All except one received a proton-pump inhibitor, amoxicillin, and levofloxacin. One received a proton-pump inhibitor, amoxicillin, levofloxacin, and clarithromycin, and the eradication was successful. Thirty-one were administered the therapy for 7 days, 25 for 10 days, and 32 for 14 days. No significant differences were observed in the eradication rates between the three groups (7-days, 80.6% vs 10-days, 64.0% vs 14-days, 68.8%, p=0.353). Additionally, no differences were found in the eradiation rates according to the type of peptic ulcer (gastric ulcer, 73.2% vs duodenal/gastroduodenal ulcer, 68.8%, p=0.655).
Conclusions: Levofloxacin-based third-line H. pylori eradication showed efficacy similar to that of previously reported first/second-line therapies.
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KEYWORD
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Levofloxacin, Helicobacter pylori, Third-line eradication
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